In approximately 249 BC, her father died, making Berenice ruling queen of Cyrene. Soon after her father died, Berenice was married to Demetrius the Fair, a Macedonian prince.
After Demetrius came to Cyrene, he became the lover of her mother, Apama. In a dramatic event, Bernice had him killed in Apama's bedroom. Berenice stood at the door and instructed the hired assassins not to hurt her mother while she attempted to protect Demetrius.
After the death of Demetrius, Berenice married Ptolemy III. Soon after her second husband's death in 221 BC, she was murdered at the instigation of her son, Ptolemy IV, with whom she probably was associated in the government.
Reverse: BAΣIΛEΩΣ ΠTOΛEMAIOY, eagle standing left on thunderbolt, wings closed.
Die Orientation: 12 H
Weight: 8.78 g
Reverse: PO Prow of galley to right; above, rose. R
Die Orientation: 11 H
Weight: 2.19 g
Ashton connects this issue showing a female bust on the obverse with the disaster relief sent by Ptolemy III to Rhodes after the devastating earthquake of circa 226 BC. According to Strabo, the earthquake toppled the Colossus of Rhodes, but an oracle from Delphi told the Rhodians not to rebuild it as its construction had offended Helios. Ptolemy's offer to pay for the reconstruction of the magnificent statue was hence turned down, and his aid was used to rebuild the city instead.