Edessa (Mesopotamia) - A settlement in Mesopotamia and Osroene
Edessa was a city in Upper Mesopotamia, founded on an earlier site by Seleucus I Nicator ca. 302 BC. It was also known as Antiochia on the Callirhoe from the 2nd century BC. It was the capital of the semi-independent kingdom of Osroene from c. 132 BC and fell under direct Roman rule in ca. 242.

It became an important early centre of Syriac Christianity. It fell to the Muslim conquest in 639, was briefly re-taken by Byzantium in 1031, and became the center of the Crusader state of the County of Edessa during 1098–1144. It fell to the Turkic Zengid dynasty in 1144 and was eventually absorbed by the Ottoman Empire in 1517.

Modern location: Urfa, Turkey

(1) Gordian III | Abgar X Frahad bar Manu 241-244 AD
Obverse: radiate, draped and cuirassed bust of Gordian III right from behind; star right AVTOK K M ANT ΓOPΔIANOC CEB
Reverse: bearded draped bust of Abgar X Frahad bar Manu right wearing diademed tiara; star left; ABΓAPOC BACIΛEVC
Ref: SNG Cop 227
(2) Macrinus 217-218 AD
Obverse: laureate, draped and cuirassed bust right
Reverse: eagle facing, head right, wreath in beak, shrine below; ΔHMAP·X·EΞ VΠATOC
Ref: Prieur 860 (same obverse die)