Coins from Mesopotamia and Osroene
Mesopotamia is a historical region in West Asia situated within the Tigris–Euphrates river system.

The Sumerians and Akkadians (including Assyrians and Babylonians) dominated Mesopotamia from the beginning of written history (c. 3100 BC) to the fall of Babylon in 539 BC, when it was conquered by the Achaemenid Empire. It fell to Alexander the Great in 332 BC, and after his death, it became part of the Greek Seleucid Empire.

Osroene was a historical region in Upper Mesopotamia. It enjoyed semi-autonomy to complete independence from the years of 132 BC to AD 216.

Mesopotamia and Osroene